Development of A Nano-Apatite Based Composite Sealer for Endodontic Root Canal Filling

Recently, endodontic sealers based on injectable bioactive materials were proposed to improve the filling of anatomical irregularities during root canal obturation. In this context, preliminary work investigated possibility realizing a new calcium phosphate-based composite sealer for with an optimized composition setting kinetics and dentin tubules occlusion. Several phosphate/liquid phase mixtures initially evaluated their workability, finding two suitable formulations. Both them contained 66 wt.% nano-apatite-based cement (solid powdered phase). The liquid (34 wt.%) comprised 13.6% propanediol 20.4% PEG 1000 (formulation 1), formulation 2 27.2% glycerin 6.8% 200 2). Then, these formulations tested by means permeability measurements observation scanning electron microscopy treated model samples. succeeded in occluding dentinal tubules: first one was able create full-bodied layer surface and, moreover, resist, at least large extent, against citric acid attack. second showed lower effectiveness after exposure. compound that better satisfied overall required characteristics use, workability sealing capacity 1.